Scientific Publications

Hypoactive Sexual Desire Disorder (HSDD) is not ‘Female Erectile Dysfunction (ED)’: Challenges with the Characterization of HSDD in Women Based on a Systematic Literature Review

Hypoactive sexual desire disorder (HSDD) in women has been viewed inaccurately by some in the medical and payer community as analogous to erectile dysfunction (ED) in men. This literature review aims to highlight the distinctions between HSDD and ED. Authors Sheryl Kingsberg, Shruti Nambiar, Swagata Karkare, Nandini Hadker, Michelle Lim-Watson, Laura Williams, Julie Krop Journal National Library of Medicine; Current Medical Research & Opinion; June 2020 View publication…

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Scientific Publications

Real-World Evidence on Patients with Non-Muscle Invasive Bladder Cancer Treated with BCG Therapy

This retrospective patient medical chart study aimed to assess the treatment patterns and real-world practice outcomes of NMIBC patients who were treated with BCG. Authors Sam Chang, Kyle Martin, Dan Shaffer, Amy Guo, Nandini Hadker Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Assessing the Real-World Inpatient Treatment Paradigm for Recurrent Clostridium Difficile

This analysis of real-world hospital data aimed to characterize the treatment regimens for inpatients experiencing rCDI, including both hospital- and community-acquired recurrence, and to compare these regimens to current treatment guidelines. Authors Gavin Miyasato, Hannah Li, Dushyant Katariya, Kevin Francis, Nandini Hadker Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Network Meta-Analyses of Real-World Evidence: A Systematic Review of Methods

Network meta-analysis (NMA) compares multiple health technologies when there is a lack of direct evidence with randomized controlled trials (RCT) alone. While supplementing RCTs with robust real-world evidence (RWE) in NMAs has become standard practice, NMAs of RWE alone are now being used to gain insights into the patient experience in clinical practice. This SLR aimed to assess the quality of published RWE-only NMAs and evaluate the statistical methods used to account for clinical and statistical heterogeneity. Authors Nambiar S,…

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Scientific Publications

Cost of Care Analysis for U.S. Patients with Prader-Willi Syndrome (PWS)

This study analyzed direct medical costs of PWS patients and compared these to non-PWS patients; cost variation between those receiving growth hormone (GH) and those not was also evaluated. Authors Justin Li, David Yin, Qian Meng, Abigail Silber, Sina Aghsaei, Kevin Francis, Nandini Hadker, Theresa Strong, Jennifer Miller, Merlin Butler, Ann Manzardo, Michael Yeh, Shawn Czado Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Comparison of Cesarean Section and Hysterectomy Outcomes Between Topical Powered Hemostat Cohorts: A Retrospective Analysis

The purpose of this systematic literature review (SLR) was to assess current data on burden of survival for pediatric CXTpatients receiving platinum-based regimens in terms of hearing loss, specifically related to costs and quality of life (QoL)-based metrics. Authors Hennegan K, Silber A, Yuan A, Miyasato G, Li J, Soneji Y, Danker W Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Evaluating the Burden of Survival of Platinum-induced Hearing Loss in Pediatric Solid Tumor Patients: A Systematic Literature Review

The purpose of this systematic literature review (SLR) was to assess current data on burden of survival for pediatric CXTpatients receiving platinum-based regimens in terms of hearing loss, specifically related to costs and quality of life (QoL)-based metrics. Authors Kalin Hennegan, Abigail Silber, Sumudu Dehipawala, Kevin Chithran, Donna Lockhart Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Epidemiology and Real-World Treatment of Chronic Graft-Versus-Host Disease Post Allogeneic Hematopoietic Cell Transplantation: A US Claims Analysis

Chronic Graft-Versus-Host Disease (cGVHD) is a complication of hematopoietic cell transplantation (HCT). While the clinical outcomes of cGVHD are well documented, few studies have assessed its treatment practices in the real-world. The objectives of this study are to quantify the prevalence of cGVHD, to examine provider prescribing patterns, and to evaluate the healthcare cost and resource utilization (HCRU) in a real-world US cGVHD population. Authors Carlos Bachier, Sanjay Aggarwal, Kalin Hennegan, Andrew Milgroom, Kevin Francis, Marcello Rotta Journal Blood; American…

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Scientific Publications

Healthcare Utilization Patterns Among Commercially Insured Patients with Prader-Willi Syndrome: A Retrospective Analysis of Administrative Claims

Prader-Willi syndrome (PWS) is a complex orphan endocrine disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality along with a significant burden on patients and caregivers. Life-long medical care is required but the consistency of services rendered to this population has not been evaluated. This study characterized use of US hospital care, specialty physician care, and growth hormone (GH) therapy for PWS patients at different life stages. Authors Merlin Butler, Ann Manzardo, Theresa…

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Scientific Publications

U.S. Prevalence & Mortality of Prader-Willi Syndrome: A Population-Based Study of Medical Claims

Prader-Willi syndrome (PWS) is a complex developmental genetic disorder associated with hypotonia, poor feeding in neonates, onset of hyperphagia in early childhood, and shorter overall life expectancy. Prior epidemiology studies of PWS have examined smaller populations, with limited research in a US population. The aim of this study was to provide a contemporary estimate of PWS prevalence and annual all-cause mortality in the US using a large administrative medical claims dataset. Authors Shawn McCandless, Marissa Suh, David Yin, Michael Yeh,…

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