Scientific Publications
The purpose of this systematic literature review (SLR) was to assess current data on burden of survival for pediatric CXTpatients receiving platinum-based regimens in terms of hearing loss, specifically related to costs and quality of life (QoL)-based metrics.
Authors
Kalin Hennegan, Abigail Silber, Sumudu Dehipawala, Kevin Chithran, Donna Lockhart
Journal
ISPOR Meeting; May 2020
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Scientific Publications
Chronic Graft-Versus-Host Disease (cGVHD) is a complication of hematopoietic cell transplantation (HCT). While the clinical outcomes of cGVHD are well documented, few studies have assessed its treatment practices in the real-world. The objectives of this study are to quantify the prevalence of cGVHD, to examine provider prescribing patterns, and to evaluate the healthcare cost and resource utilization (HCRU) in a real-world US cGVHD population.
Authors
Carlos Bachier, Sanjay Aggarwal, Kalin Hennegan, Andrew Milgroom, Kevin Francis, Marcello Rotta
Journal
Blood; American…
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Scientific Publications
Prader-Willi syndrome (PWS) is a complex orphan endocrine disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality along with a significant burden on patients and caregivers. Life-long medical care is required but the consistency of services rendered to this population has not been evaluated. This study characterized use of US hospital care, specialty physician care, and growth hormone (GH) therapy for PWS patients at different life stages.
Authors
Merlin Butler, Ann Manzardo, Theresa…
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Scientific Publications
Prader-Willi syndrome (PWS) is a complex developmental genetic disorder associated with hypotonia, poor feeding in neonates, onset of hyperphagia in early childhood, and shorter overall life expectancy. Prior epidemiology studies of PWS have examined smaller populations, with limited research in a US population. The aim of this study was to provide a contemporary estimate of PWS prevalence and annual all-cause mortality in the US using a large administrative medical claims dataset.
Authors
Shawn McCandless, Marissa Suh, David Yin, Michael Yeh,…
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Scientific Publications
Prader-Willi syndrome (PWS) is a rare, complex multi-system genetic disorder characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality and to a significant burden on patients and caregivers. The hyperphagia seen in people with PWS can result in significant obesity. This study assessed rates of comorbidities associated with obesity, including type II diabetes (T2D), cardiovascular disease (CVD), and sleep apnea (SA) in a large US PWS vs. a non-PWS cohort.
Authors
Diane Stafford, Justin…
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Scientific Publications
The purpose of this study was to systematically assess the prevalence, clinical consequences, and reporting of treatment-emergent hypophosphatemia within literature investigating IVI therapies marketed in the United States (US)
Authors
John Glaspy, Michelle Lim-Watson, Michael A Libre, Swagata Karkare, Nandini Hadker, Aleksandra Bajic-Lucas, William Strauss, Naomi Dahl
Journal
Therapeutics and Clinical Risk Management
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Scientific Publications
Recent developments in digitally assisted vitreo-retinal surgery (DAVS) and heads-up setup were introduced to the global ophthalmic surgical community to enhance visualization with digital signal amplification, higher resolution, and increased depth of field, while addressing some of the ergonomic challenges associated with conventional microscopes
Authors
Leighton Morris, William Wiley, Van Sandwick, Chiraag Lathia, Hang Cheng, Dina Abulon, Nandini Hadker, Kalin Hennegan
Journal
ISPOR EU 2020
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Scientific Publications
While technological or procedural advances have resulted in low complication and re-operation rates, there are limitations of existing technologies — including but not limited to: surgical endo-illumination challenges, need for in-procedure adjustments, and additional information/support provided by other surgical devices — all of which can create challenges for surgeons during procedures
Authors
Leighton Morris, Alan Franklin, Van Sandwick, Chiraag Lathia, Hang Cheng, Nandini Hadker, Kalin Hennegan
Journal
ISPOR EU 2020
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Scientific Publications
This retrospective analysis of medical chart data was performed to compare severity and treatment of gout in patients with or without a history of kidney transplantation (KT).
Authors
Lauren Radeck, Clive M. Mendonca, Isabel Lang, Jeffrey Kent, Brian Lamoreaux, Richard J. Johnson
Journal
American Society of Nephrology Meeting, October 2018
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Scientific Publications
Hypoactive sexual desire disorder (HSDD) is the most prevalent form of female sexual dysfunction (FSD) in the United States and is characterized by a decrease or lack of sexual desire accompanied by distress. Despite the relatively high prevalence of HSDD in US women 18-44 years of age (∼10%), there is a limited understanding of the condition among physicians.
Authors
Sharon Parish, Zainab Shahpurwala, Amod Athavale, Rahul Ravindranath, Nandini Hadker, and Michelle Lim-Watson
Journal
ISSWSH / ISSM Joint Meeting, March 2019…
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