Scientific Publications

Cost of Care Analysis for U.S. Patients with Prader-Willi Syndrome (PWS)

This study analyzed direct medical costs of PWS patients and compared these to non-PWS patients; cost variation between those receiving growth hormone (GH) and those not was also evaluated. Authors Justin Li, David Yin, Qian Meng, Abigail Silber, Sina Aghsaei, Kevin Francis, Nandini Hadker, Theresa Strong, Jennifer Miller, Merlin Butler, Ann Manzardo, Michael Yeh, Shawn Czado Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Comparison of Cesarean Section and Hysterectomy Outcomes Between Topical Powered Hemostat Cohorts: A Retrospective Analysis

The purpose of this systematic literature review (SLR) was to assess current data on burden of survival for pediatric CXTpatients receiving platinum-based regimens in terms of hearing loss, specifically related to costs and quality of life (QoL)-based metrics. Authors Hennegan K, Silber A, Yuan A, Miyasato G, Li J, Soneji Y, Danker W Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Evaluating the Burden of Survival of Platinum-induced Hearing Loss in Pediatric Solid Tumor Patients: A Systematic Literature Review

The purpose of this systematic literature review (SLR) was to assess current data on burden of survival for pediatric CXTpatients receiving platinum-based regimens in terms of hearing loss, specifically related to costs and quality of life (QoL)-based metrics. Authors Kalin Hennegan, Abigail Silber, Sumudu Dehipawala, Kevin Chithran, Donna Lockhart Journal ISPOR Meeting; May 2020 View publication…

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Scientific Publications

Epidemiology and Real-World Treatment of Chronic Graft-Versus-Host Disease Post Allogeneic Hematopoietic Cell Transplantation: A US Claims Analysis

Chronic Graft-Versus-Host Disease (cGVHD) is a complication of hematopoietic cell transplantation (HCT). While the clinical outcomes of cGVHD are well documented, few studies have assessed its treatment practices in the real-world. The objectives of this study are to quantify the prevalence of cGVHD, to examine provider prescribing patterns, and to evaluate the healthcare cost and resource utilization (HCRU) in a real-world US cGVHD population. Authors Carlos Bachier, Sanjay Aggarwal, Kalin Hennegan, Andrew Milgroom, Kevin Francis, Marcello Rotta Journal Blood; American…

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Scientific Publications

Healthcare Utilization Patterns Among Commercially Insured Patients with Prader-Willi Syndrome: A Retrospective Analysis of Administrative Claims

Prader-Willi syndrome (PWS) is a complex orphan endocrine disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality along with a significant burden on patients and caregivers. Life-long medical care is required but the consistency of services rendered to this population has not been evaluated. This study characterized use of US hospital care, specialty physician care, and growth hormone (GH) therapy for PWS patients at different life stages. Authors Merlin Butler, Ann Manzardo, Theresa…

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Scientific Publications

Hypophosphatemia Associated with Intravenous Iron Therapies for Iron Deficiency Anemia

The purpose of this study was to systematically assess the prevalence, clinical consequences, and reporting of treatment-emergent hypophosphatemia within literature investigating IVI therapies marketed in the United States (US) Authors John Glaspy, Michelle Lim-Watson, Michael A Libre, Swagata Karkare, Nandini Hadker, Aleksandra Bajic-Lucas, William Strauss, Naomi Dahl Journal Therapeutics and Clinical Risk Management View publication…

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Scientific Publications

Evaluating the Ergonomic Outcomes of Digitally Assisted Vitreo-Retinal Surgery: A Systematic Literature Review

Recent developments in digitally assisted vitreo-retinal surgery (DAVS) and heads-up setup were introduced to the global ophthalmic surgical community to enhance visualization with digital signal amplification, higher resolution, and increased depth of field, while addressing some of the ergonomic challenges associated with conventional microscopes Authors Leighton Morris, William Wiley, Van Sandwick, Chiraag Lathia, Hang Cheng, Dina Abulon, Nandini Hadker, Kalin Hennegan Journal ISPOR EU 2020 View publication…

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Scientific Publications

Evaluating the Level of Endo-illumination Required during Digitally Assisted Vitreo-Retinal Surgery (DAVS): A Systematic Literature Review

While technological or procedural advances have resulted in low complication and re-operation rates, there are limitations of existing technologies — including but not limited to: surgical endo-illumination challenges, need for in-procedure adjustments, and additional information/support provided by other surgical devices — all of which can create challenges for surgeons during procedures Authors Leighton Morris, Alan Franklin, Van Sandwick, Chiraag Lathia, Hang Cheng, Nandini Hadker, Kalin Hennegan Journal ISPOR EU 2020 View publication…

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Scientific Publications

Gout Severity in Recipients of Kidney Transplant

This retrospective analysis of medical chart data was performed to compare severity and treatment of gout in patients with or without a history of kidney transplantation (KT). Authors Lauren Radeck, Clive M. Mendonca, Isabel Lang, Jeffrey Kent, Brian Lamoreaux, Richard J. Johnson Journal American Society of Nephrology Meeting, October 2018 View publication…

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Scientific Publications

Describing the Clinical Approach to Diagnosis and Treatment of Patients with Hypoactive Sexual Desire Disorder

Hypoactive sexual desire disorder (HSDD) is the most prevalent form of female sexual dysfunction (FSD) in the United States and is characterized by a decrease or lack of sexual desire accompanied by distress. Despite the relatively high prevalence of HSDD in US women 18-44 years of age (∼10%), there is a limited understanding of the condition among physicians. Authors Sharon Parish, Zainab Shahpurwala, Amod Athavale, Rahul Ravindranath, Nandini Hadker, and Michelle Lim-Watson Journal ISSWSH / ISSM Joint Meeting, March 2019…

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