Home / Intelligence / Scientific Publications / U.S. Prevalence & Mortality of Prader-Willi Syndrome: A Population-Based Study of Medical Claims
Prader-Willi syndrome (PWS) is a complex developmental genetic disorder associated with hypotonia, poor feeding in neonates, onset of hyperphagia in early childhood, and shorter overall life expectancy. Prior epidemiology studies of PWS have examined smaller populations, with limited research in a US population. The aim of this study was to provide a contemporary estimate of PWS prevalence and annual all-cause mortality in the US using a large administrative medical claims dataset.
Authors
Shawn McCandless, Marissa Suh, David Yin, Michael Yeh, Shawn Czado, Sina Aghsaei, Justin Li, Kevin Francis, Nandini Hadker, Diane Stafford
Journal
Journal of the Endocrine Society; Volume 4; Issue Supplement_1; April-May 2020
Related Intelligence
Webinars
Most-Favored Nation Pricing Policy: Why One Size Doesn’t Fit All
September 25, 2025 | 1:00 – 2:00 PM ET
As U.S. leaders promote a drug pricing vision based on Most-Favored Nation (MFN) principles, ensuring that U.S. consumers have access to the best available prices among advanced nations, pharmaceutical companies are facing increased uncertainty and are evaluating strategic options. This session will bring together Trinity experts to discuss how this initiative could realistically lead to […]
Sign Up Now
Blog
A Shrinking Safety Net: OBBBA’s Ripple Effects on the Pharma Industry
President Trump signed the “One Big Beautiful Bill Act” (OBBBA) into law on July 4, 2025. The OBBBA is projected to reduce federal health spending by an estimated $900 billion[1] over the next decade. Central to the legislation is the estimated loss of insurance coverage for 16 million people[2], fundamentally reshaping access to care for […]
Read More
Webinars
Unlocking Medical Impact with AI
September 18, 2025 | 1:00 – 1:45 PM ET
Medical Affairs teams are under growing pressure to deliver faster insights, smarter engagement, and measurable value—yet many are limited by manual processes, fragmented data, and time-intensive workflows. Join us for the next webinar in our “AI Innovations in Life Sciences” series, where Trinity experts will show how it is possible with AI to unlock deeper, novel insights, power efficient workflows, and drive greater impact in the Medical Affairs field and headquarters functions.
Sign Up Now